Nephropathy refers to damage, disease , or other abnormalities of the kidney. IgA nephropathy is a kidney disorder in which antibodies to a protein called IgA build up in kidney tissue.
It is also called Berger’s disease.
IgA is a protein that helps the body fight infections. IgA nephropathy (Berger's disease) occurs when too much of this protein is deposited in the kidneys. IgA builds up inside the small blood vessels of the kidney. Structures in the kidney called glomeruli become inflamed.
IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis.
The disorder can appear suddenly (acute), or progress slowly over many years (chronic glomerulonephritis).
Risk factors include:
There may be no symptoms for many years.
IgA nephropathy usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder.
There are no specific changes seen during a physical examination. Occasionally, blood pressure may be high or swelling of the body may be present.
The goal of treatment is to relieve symptoms and prevent or delay chronic renal failure.
Medicines may be given to control high blood pressure and swelling (edema). Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are used. Controlling blood pressure is the most important measure to delay kidney damage.
Corticosteroids, other immunosuppressive drugs, and fish oil have also been used to treat this disorder.
Salt and fluids may be restricted to control swelling. A low to moderateprotein diet may be recommended in some cases.
Some people will need to take medicines to lower their cholesterol.
Eventually, many patients must be treated for chronic kidney disease.
IgA nephropathy progresses slowly. In many cases, it does not progress at all. High blood pressure, large quantities of protein in the urine, and increased BUN or creatinine levels (blood tests that reflect kidney functioning) indicate a higher risk for progression of the disorder.
About 25% of adults with IgA nephropathy develop end-stage kidney failure within about 25 years.
Call your health care provider if you have bloody urine or if your urine output decreases.
Treating disorders such as high blood pressure can help prevent acute kidney failure.
Nephropathy - IgA; Berger's disease